Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp170 | Cell biology: osteoclasts and bone resorption | ECTS2014

DBZ, a γ-secretase inhibitor, suppresses bone resorption by inhibiting c-Src activity

Jin Won Jong , Kim Ha-Neui , Kim Hong-Hee , Lee Zang Hee

Tyrosine kinase c-Src plays an important role in actin ring formation and bone resorption activity in osteoclasts. Therefore, c-Src has been targeted for the treatment of osteolytic disorders. In the present study, we investigated anti-resorptive effect of dibenzazepine (DBZ), one of the γ-secretase inhibitors (GSIs), on osteoclast-mediated excessive bone resorption. DBZ did not affect osteoclast differentiation, but disturbed actin ring formation and inhibited osteoclast...

ba0001pp151 | Cancer and bone: basic, translational and clinical | ECTS2013

Trolox inhibits breast cancer bone metastasis and bone destruction through suppression of PGE2 production

Lee Jong-Ho , Ha Hyunil , Jin Won Jong , Kim Sun-Don , Jung Jin Suk , Hong-Hee Kim , Lee Zang Hee

The skeleton is a preferred site of metastasis in patients with advanced breast cancer, and bone loss is one of the major complications of breast cancer metastasis. Therefore, prevention of bone metastasis is clinically important. Our previous observation of an anti-osteoclastic activity of Trolox, a vitamin E analogue, led us to investigate whether Trolox could inhibit bone metastasis and bone destruction induced by breast cancer. I.P. administration of Trolox markedly inhibi...