Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp378 | Other diseases of bone and mineral metabolism | ECTS2014

Zoledronic acid induces apoptosis on osteoblast and inhibits RANKL-induced osteoclast differentiation

Lim Shin Saeng , Kim In Sook , Hwang Soon Jung

Bisphosphonates (BPs) are widely used as antiresorptive drugs. However, one of most potent BPs, zoledronic acid (ZA) can cause BP-related osteonecrosis of the jaws (BRONJ) with a poorly understood pathophysiology. The aim of this study was to find a clue for the development of BRONJ by evaluating the cytotoxic effects of ZA on osteoblasts and examining the action mechanism of ZA on osteoclast differentiation. Jaw bone osteoblasts (JB-OBs), long bone osteoblasts (LB-OBs), and b...

ba0005p156 | Cell biology: osteoblasts and bone formation | ECTS2016

The differential effects of zoledronate and etidronate on the in vivo early osseous healing process of an extracted socket and a tibial defect

Kim In Sook , Lim Shin Saeng , Lee Beomseok , Hwang Soon Jung

Bisphosphonates (BPs) are widely used for treating osteoporosis and preventing osseous metastasis or hypercalcemia in cancers. However, osteonecrosis of the jaw in patients treated with BP after dentoalveolar surgery has been increasing, especially in those treated with strong BPs such as zoledronate (ZA). The pathobiology underlying the occurrence of osteonecrosis only in the jaw bone remains unclear. The objective of this study was to compare the effects of BPs on the in...