Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp280 | Genetics | ECTS2013

Association between dentinogenesis imperfecta and mutations in COLIA1 and COLIA2 genes

Andersson Kristofer , Dahllof Goran , Astrom Eva , Rubin C-J , Kindmark A , Lindahl Katarina , Ljunggren Osten , Malmgren Barbro

Introduction: Dentinogenesis imperfecta (DI) is a common dental aberration in patients with osteogenesis imperfecta (OI). Mutations that cause abnormal collagen chains will cause more serious types of OI and it has been claimed that DI should be a marker for qualitative defected collagen. It has also been supposed that normal development of teeth may be more dependent on normal α2(I) than normal α1(I) chains which are encoded by COLIA2 and COLIA1 ge...

ba0001pp492 | Other diseases of bone and mineral metabolism | ECTS2013

Allele dependent silencing of collagen type I using small interfering RNAs targeting 3′UTR indels – a novel therapeutic approach in osteogenesis imperfecta

Lindahl Katarina , Kindmark Andreas , Laxman Navya , Astrom Eva , Rubin Carl-Johan , Ljunggren Osten

Abstract: Osteogenesis imperfecta, also known as ‘brittle bone disease’, is a heterogeneous disorder of connective tissue generally caused by dominant mutations in the genes COL1A1 and COL1A2, encoding the α1 and α2 chains of type I (pro)collagen. Symptomatic patients are usually prescribed bisphosphonates, but this treatment is neither curative nor sufficient. A promising field is gene silencing through RNA interference. In this study, small interfering RN...

ba0001pp429 | Osteoporosis: treatment | ECTS2013

Study description and baseline characteristics of the population enrolled in the extended forsteo® observational study (ExFOS)

Langdahl Bente , Benhamou Claude , Lindh Erik , Dekker Joannes , Kapetanos Giorgios , Kocjan Tomaz , Ljunggren Osten , Napoli Nicola , Petto Helmut , Nicolic Tatjana

ExFOS is a multicenter, prospective, observational study to evaluate fracture outcomes, back pain, compliance and health-related quality of life in female and male patients with osteoporosis treated with teriparatide [rhPTH(1–34)] (Forsteo)for 18 to 24 months. Post-treatment follow-up will last for at least 18 months. Patients were enrolled in Croatia, Denmark, France, Greece, Italy, Norway, Slovenia, and Sweden. The study design was non-interventional and all consenting ...

ba0005oc3.5 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Low serum iron is associated with high serum FGF23 in elderly men: the Swedish MrOS study

Lewerin Catharina , Ljunggren Osten , Nilsson-Ehle Herman , Karlsson Magnus K , Herlitz Hans , Lorentzon Mattias , Ohlsson Claes , Mellstrom Dan

Introduction: Fibroblast growth factor (FGF23) is a hormone derived from osteoblasts and osteocytes being involved in calcium and phosphate homeostasis, where serum iron (S-Fe) has been suggested as a potential mediator of FGF23 regulation. The aim was to determine whether iron status is a determinant of FGF23 in elderly men.Methods: The MrOS (osteoporotic fractures in men is a population based study of elderly men, in the Gothenburg part, (median age of...