Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p120 | Cancer and bone: basic, translational and clinical | ECTS2016

The role of acidic microenvironment in the context of osteolytic carcinomas

Di Pompo Gemma , Lemma Silvia , Canti Lorenzo , Gillies Robert , Baldini Nicola , Avnet Sofia

The microenvironment of osteolytic metastases includes carcinoma cells derived from the primary lesion as well as bone-forming and bone-resorbing cells, namely osteoblasts (OB) and osteoclasts (OC). At this site, both the high glycolysis of cancer cells, and the bone resorption process result in a very acidic milieu. This, in turn, induces the surrounding stroma and OB to secrete pro-inflammatory cytokines and growth factors that promote tumorigenesis and cancer-associated ost...