Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp368 | Other diseases of bone and mineral metabolism | ECTS2014

Vitamin D supplementation decreases the occurrence of acute phase response following i.v. bisphosphonate treatment in Paget's disease of bone

Merlotti Daniela , Gennari Luigi , Franci Maria Beatrice , Lucani Barbara , Campagna Maria Stella , Cresti Laura , Stolakis Konstantinos , Rotatori Stefano , Nuti Ranuccio

Acute phase reaction (APR) is the most frequent side effect following i.v. nitrogen-containing bisphosphonates (N-BPs) infusion. A recent observation in osteoporotic women treated with N-BPs evidenced a negative association between 25(OH)D levels and APR, likely due to the immuno-modulatory effects of vitamin D on γδTcells. However, this association remains to be demonstrated in patients with Paget’s disease of bone (PDB). Moreover whether vitamin D supplementat...

ba0003pp186 | Genetics | ECTS2014

Pharmacogenomics of bisphosphonate treatment in Paget's disease of bone: retrospective and prospective analysis

Merlotti Daniela , Gianfrancesco Fernando , Rendina Domenico , Muscariello Riccardo , Esposito Teresa , Franci Maria Beatrice , Lucani Barbara , Campagna Maria Stella , Cresti Laura , Strazzullo Pasquale , Nuti Ranuccio , Gennari Luigi

We previously evidenced a reduced response to i.v. pamidronate in Q15STM1 mutation carriers (Q15STM1+) with Paget’s disease of bone (PDB). In order to confirm and extend this observation, we investigated the effect of Q15STM1 mutation and polymorphisms in three genes associated with PDB (TNFRSF11A; OPTN; TNFRSF11B) on the response to bisphosphonates. First, a retrospective study was performed in 335 patients treated wi...

ba0005p367 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

FGF23 and SCL are expressed in carotid plaques and the association between their circulating fractions and fractures differs in relation to comorbidity in elderly individuals

Rotatori Stefano , Corallo Claudio , Merlotti Daniela , Rendina Domenico , Bianciardi Simone , Patti Aurora , Gonnelli Stefano , Evangelista Isabella Anna , Lucani Barbara , Franci Maria Beatrice , Setacci Carlo , Strazzullo Pasquale , Nuti Ranuccio , Dotta Francesco , Gennari Luigi

Sclerostin (SCL) and FGF23 are osteocyte-secreted factors with a major role in bone homeostasis. Despite their skeletal effects and their association with fracture risk in some studies, variations in circulating levels were also described in patients with diabetes (DM), chronic renal failure (CRF) and/or cardiovascular disease (CVD). In order to provide further insight on the relationship between these osteocyte-derived factors, osteoporosis and cardio-metabolic disorders we a...