Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp173 | Cell biology: osteoclasts and bone resorption | ECTS2014

Inhibition of bone remodeling by bisphosphonate displaces the plasma cell niche into the spleen

Teufel Stefan , Grotsch Bettina , Luther Julia , Schinke Thorsten , Amling Michael , Schett Georg , Mielenz Dirk , David Jean-Pierre

Bone marrow is the main hematopoietic organ of adults. There, hematopoietic stem cells from which all hematopoietic lineages can be generated are preferentially homing. Importantly, bone provides niches for early B cell differentiation and survival of long-lived plasma cells that produced antibodies. Thus, that perturbing bone homeostasis might impact B cell function and antibody production is a highly relevant hypothesis for patients receiving antiresorptive drugs.<p clas...