Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp167 | Cell biology: osteoblasts and bone formation | ECTS2013

Adipogenesis occurs at the expense of osteoblast differentiation in primary osteoblasts deficient in protease-activated receptor 2

Kularathna Pamuditha , Pagel Charles N , Hooper John D , Mackie Eleanor J

The G protein-coupled receptor, protease-activated receptor 2 (PAR2), is expressed by osteoblasts and required for normal skeletal growth and repair. Prostate cancer (PCa) cells commonly secrete proteolytic activators of PAR2 (including matriptase and kallikrein-related peptidase 4) and frequently form osteogenic metastases in bone. This study was undertaken to investigate the hypothesis that PAR2 activators released by PCa cells modulate osteo...