Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc3.6 | Osteoporosis pathophysiology and genetics | ECTS2013

Causal metabolomic pathways to osteoporosis in elderly women

Moayyeri Alireza , Hart Deborah , Erte Idil , Mangino Massimo , Hammond Christopher , Spector Timothy

Background: Recent technological ‘omics’ advances have empowered us to identify associations between genetic markers and various traits. Knowledge of serum metabolites as intermediary phenotypes can help us achieve a better understanding of the causal pathways from genes to complex diseases like osteoporosis.Methods: In the context of TwinsUK study, serum metabolomic profiles of 6055 participants were assessed using a non-targeted mass spectrom...