Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp151 | Cell biology: osteoblasts and bone formation | ECTS2014

Syndecan-2 is a new negative modulator of Wnt signaling within bone marrow

Mansouri Rafik , Geoffroy Valerie , Marie Pierre , Modrowski Dominique

Wnt factors bind to heparan sulfate chains of syndecans that hence control their distribution in the cell microenvironment and also contribute to the internalization and recycling of the Wnt receptors. Syndecans are therefore likely important Wnt regulators within the bone marrow. Here, we investigated the interactions between Syndecan-2 and Wnt signaling in normal bone cells. We analyzed the effects of 2.3 kb Col1A1 promoter-driven Syndecan-2 overexpression in osteoblasts. Sy...