Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp180 | Cell biology: osteoblasts and bone formation | ECTS2013

N-cadherin governs age-related osteoprogenitor cell determination in mice through modulation of Wnt5a and Wnt10b

Hay Eric , Dieudonne Francois-Xavier , Marty Caroline , Marie Pierre J

Senile osteoporosis and age-related osteopenia are associated with decreased osteoblastogenesis and increased bone marrow adipogenesis. The mechanisms controlling the fate determination of osteoblast to adipocyte differentiation of bone marrow stromal cells (BMSC) during aging are not known. We and others previously showed that the cell-cell adhesion molecule N-cadherin (N-Cadh) expressed in osteoblasts controls bone formation, but little is known about its role in BMSC fate d...

ba0003pp151 | Cell biology: osteoblasts and bone formation | ECTS2014

Syndecan-2 is a new negative modulator of Wnt signaling within bone marrow

Mansouri Rafik , Geoffroy Valerie , Marie Pierre , Modrowski Dominique

Wnt factors bind to heparan sulfate chains of syndecans that hence control their distribution in the cell microenvironment and also contribute to the internalization and recycling of the Wnt receptors. Syndecans are therefore likely important Wnt regulators within the bone marrow. Here, we investigated the interactions between Syndecan-2 and Wnt signaling in normal bone cells. We analyzed the effects of 2.3 kb Col1A1 promoter-driven Syndecan-2 overexpression in osteoblasts. Sy...

ba0001pp468 | Other diseases of bone and mineral metabolism | ECTS2013

Miglustat therapy normalizes bone mass in a mouse model of cystic fibrosis

Henaff Carole Le , Hay Eric , Velard Frederic , Marty Caroline , Marie Pierre J , Jacquot Jacky P

Brittle bones have been reported in children, adolescents and adults with cystic fibrosis (CF), independently of sex; this has been termed CF-related bone disease. In CF patients with the F508del mutation in the (Cftr) gene, vertebral fractures and the subsequent dorsal kyphosis decrease pulmonary function, thus accelerating the course of the disease. Mice with the homozygous F508del mutation in CFTR develop a severe osteopenic phenotype early on, in both sexes (Le He...

ba0003pp14 | Arthritis and other joint diseases: translational and clinical | ECTS2014

Effect of risedronate on painful periprosthetic resorption of total hip arthroplasty: preliminary observational study

Behra-Marsac Aurelie , Bonnet Christine , Mabit Christian , Coste Cedric , Preux Pierre-Marie , Vergne-Salle Pascale , Dufauret-Lombard Carine , Treves Richard , Bertin Philippe

Total hip arthroplasty (THA) is the treatment for severe hip osteoarthritis. It improves the quality of life, pain and patient autonomy. However, a periprosthetic resorption may occur, in 3–5% of patients after 10 years of the primary surgery requiring implant replacement. Bisphosphonates (BP), inhibitors of bone resorption, represent a potential candidate for modulating periprosthetic bone loss. Randomized controlled trials have also suggested that BP could prevent early...