Searchable abstracts of presentations at key conferences on calcified tissues

ba0002op13 | (1) | ICCBH2013

Long-term effects of bisphosphonate therapy in children with osteogenesis imperfecta

Biggin Andrew , Zheng Linda , Briody Julie , McQuade Mary , Munns Craig

Objectives: To evaluate the clinical outcomes of intravenous bisphosphonate treatment in children with mild-moderate osteogenesis imperfecta (OI) who had progressed from active bisphosphonate treatment to maintenance therapy for >2 years.Methods: A retrospective review was conducted on 17 patients with mild-moderate OI. Clinical data, fracture history, biochemistry, dual energy X-ray absorptiometry (DXA) parameters, vertebral measurements, bone age a...

ba0002p37 | (1) | ICCBH2013

Reduction in bisphosphonate side effect profile using short-term steroid cover

Biggin Andrew , McLean Tina , McQuade Mary , Cowell Chris , Munns Craig

Objectives: Bisphosphonate infusions are associated with numerous adverse effects including acute systemic inflammatory reactions and electrolyte abnormalities. The aims of this study were to evaluate the safety and efficacy of a 3-day course of prednisone on children receiving their first dose of pamidronate or zoledronic acid.Methods: A retrospective cohort of 166 patients (85 males) were commenced on pamidronate (16%) or zoledronic acid (84%) for trea...