Searchable abstracts of presentations at key conferences on calcified tissues

ba0005s4.2 | East Meets West | ECTS2016

Relevance of vitamin D to pathogenesis and treatment of osteoporosis

Matsumoto Toshio

In order to maintain bone remodeling balance, it is important to keep enough Ca absorption from the intestine. Vitamin D is required to increase Ca absorption from the gut. Because vitamin D acts via activation to 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney, native vitamin D cannot exert its full effect when the activation process is disturbed. Renal impairment is the main cause of deterioration of the activation of vitamin D. Aging is associated with the dev...

ba0003pp105 | Cell biology: osteoblasts and bone formation | ECTS2014

Reduced bone formation and increased adiposity with insulin resistance in interleukin-11 deficient mice

Dong Bingzi , Kondo Takeshi , Ohnishi Yukiyo , Endo Itsuro , Abe Masahiro , Aizawa Shinichi , Sakaue Hiroshi , Matsumoto Toshio

We previously reported that interleukin (IL)-11 plays an important role in the mechanical stress and PTH-induced stimulation of osteoblast differentiation and bone formation. Mechanical stress and PTH enhance IL-11 gene promoter activity and increase IL-11 expression. Increased IL-11 down-regulates dikkopf 1/2 (Dkk1/2) expression and stimulates canonical Wnt signaling, which enhances osteoblast differentiation. The present study was undertaken to clarify the physiological role...