Searchable abstracts of presentations at key conferences on calcified tissues

ba0001s2.1 | Muscles and bone | ECTS2013

Skeletal muscle loss: sarcopenia and inactivity

McArdle Anne

Age-related loss of skeletal muscle mass and function is a major cause of loss of mobility, increased frailty and falls in the elderly and impacts profoundly on the quality of life of older people. Modified reactive oxygen species (ROS) generation has been implicated in the mechanisms by which muscle function is lost with increasing age. ROS are increased in skeletal muscles of adult mice following a period of isometric contractions and this is associated with adaptive increas...