Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p246 | Genetics and Epigenetics | ECTS2016

In a population based association study: IAPP gene variants are not associated with bone phenotypes in elderly women

Mitchell Adam , Grabowski Peter , Luthman Holger , Akesson Kristina , McGuigan Fiona

Skeletal strength, maintained through bone remodelling, is regulated through complex communication networks between bone cells and other tissues including endocrine cells. Bone also functions as an endocrine organ in its own right. The peptide hormone amylin (or Islet Amyloid Polypeptide (IAPP)), has links to both bone and energy metabolism. A member of the calcitonin family of peptides, it is co-secreted with insulin from pancreatic β-cells and is linked with diabetes-as...

ba0005p364 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Peak bone mass and quantitative ultrasound bone properties in young adulthood: a study in the PEAK-25 cohort

Sandstrom Linnea , McGuigan Fiona , Callreus Mattias , Akesson Kristina

Peak bone mass, typically reached in the third decade, is the highest bone mass acquired after completion of normal growth. Attaining a higher young adult bone mass may contribute to a lower risk of fragility fractures later in life. Few studies have specifically investigated quantitative ultrasound (QUS) in relation to peak bone mass in young adult women. The study objectives were to describe normative QUS values for 25 year old women and how extremes of body weight relate to...

ba0005oc2.3 | Bone mass and bone strength Wnt signalling | ECTS2016

Life-course GWAS approach for total body BMD unveils 16 new BMD loci with some exerting age-specific effects

Medina-Gomez Carolina , Kemp John , Chesi Alessandra , Kreiner-Moller Eskil , Harris Tamara , Mook Dennis , Hatwig Fernando , Joro Raimo , Nedeljkovic Ivana , Evans Dan , Mullin Benjamin , Ohlsson Claes , Styrkarsdottir Unnur , Karasik David , McGuigan Fiona , Kiel Doug , Uitterlinden Andre , Tobias Jon , Evans Dave , Rivadeneira Fernando

Introduction: Bone mineral density (BMD) is a highly heritable trait used to assess skeletal health in children and risk of osteoporosis later in life. To date >60 loci associated with bone-related traits measured at different skeletal sites have been identified. We conducted a genome-wide association study (GWAS) meta-analysis of total body (TB-)BMD in children and adults to identify genetic determinants and age-specific effects of loci on this trait.<p class="abstext...