Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp223 | Cell biology: osteoclasts and bone resorption | ECTS2013

Methylation is not involved in repression of ADRA2A in osteocytes

Mlakar Vid , Zupan Janja , Marc Janja , Mlakar Simona Jurkovic

Osteoporosis is an age related disease characterised by a progressive decrease of bone mineral density and loss of bone quality. Twin studies show that genetic component contributes up to 85% of the BMD variability of population. Surprisingly little variability of BMD can be explained by genetic polymorphisms (~2.9%). This highlights the complex genetic architecture and suggests that many other molecular processes and genes have to be involved. Our previous research showed tha...

ba0005p248 | Genetics and Epigenetics | ECTS2016

Identification and functional validation of microRNA expression in human bone tissue

Ostanek Barbara , Bedrac Simona Mencej , Kern Barbara , Vrtacnik Peter , Mlakar Vid , Bego Tamer , Komadina Radko , Trebše Rihard , Marc Janja

miRNAs are epigenetic regulators of gene expression, increasingly recognised as prominent regulators of bone metabolism. Following our in vitro studies of miRNAs profiles in osteoblasts we extended the research to human bone samples. Our aim was to find and functionally validate miRNAs differentially expressed in osteoporotic and osteoarthrotic bone with potential for targeting genes relevant in bone metabolism.Trabecular bone tissue samples wer...