Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p10 | Arthritis and other joint diseases: translational and clinical | ECTS2016

Identifying cell populations coupling inflammation to osteoresorption in arthritis

Mosler Elvira Lazic , Flegar Darja , Sucur Alan , Fadljevic Martina , Kelava Tomislav , Markotic Antonio , Ivcevic Sanja , Zrinski-Petrovic Katerina , Katavic Vedran , Grcevic Danka , Kovacic Natasa

Rheumatoid arthritis (RA) is characterised by periarticular bone destruction leading to permanent disability. Some other forms of arthritis, such as arthritis in systemic lupus erythematosus (SLE), rarely produce bone lesions. Corresponding to that, inactivation of Fas produces a murine SLE-like phenotype, but alleviates bone loss during antigen-induced arthritis (AIA). Aim of this study was to identify cell populations differentially regulated in non-resorptive vs. resorptive...