Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp166 | Cell biology: osteoclasts and bone resorption | ECTS2014

Functional read out of perturbed osteoclast behaviour in an in vitro model of Gaucher's disease

Nijjar Sarbjit , Gittoes Neil , Geberhiwot Tarekegn

Gaucher’s disease is a glycolipid storage disorder caused by an autosomally inherited deficiency of the lysosomal enzyme glucocerebrosidase. The majority of patients with Gaucher’s disease develop abnormal bone remodelling with severe consequences, including osteonecrosis, bone crises, and osteoporosis related fractures. Although enzyme replacement therapy is effective at reversing many of the pathological consequences, and preventing further progression of this dise...