Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p49 | Bone development/growth and fracture repair | ECTS2016

The effects of combined teriparatide and denosumab on bone regeneration

Kitaguchi Kazuma , Kashii Masafumi , Sugiura Tsuyoshi , Tokimitsu Morimoto , Noguchi Takaaki , Makino Takahiro , Ebina Kosuke , Kaito Takashi , Yoshikawa Hideki

Objective: The purpose of this study is to investigate the effects of the combined teriparatide (TPTD) and denosumab (DMAB) on both cortical and cancellous bone regeneration.Materials and methods: Bone defects were created in the diaphysis of the right femur and in the epimetaphysis of the left femur in 8-week old female C57/BL6N mice. After making bone defects, Mice were given either saline or 40 μg/kg TPTD for 20 days (5× per week) and were s...