Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p488 | Preclinical and ex vivo imaging | ECTS2016

Mandibular bone: an unusual trabecular bone?

Coutel Xavier , Olejnik Cecile , Marchandise Pierre , Chauveau Christophe , Penel Guillaume

Introduction: Mandibular alveolar bone appears to be particularly sensitive to local factors compared to other skeletal sites. In growing rats, occlusal hypofunction leads to a dramatic decrease of the alveolar bone microarchitecture. Intra-radicular bone surrounding teeth is a specific functional area with a high bone turnover. We hypothesized that the mechanical loading of the alveolar process during mastication may play a role in the preservation of the alveolar bone microa...

ba0001pp38 | Bone biomechanics and quality | ECTS2013

Bisphosphonate influence on bone quality at molecular level: study of human jaw bone sequesters by Raman microspectroscopy

Olejnik Cecile , Falgayrac Guillaume , During Alexandrine , Vieillard Marie-Helene , Maes Jean Michel , Cortet Bernard , Penel Guillaume

Bisphosphonates (BP) are used as anti-resorptive drugs in benign (osteoporosis) and malignant (myeloma, bone metastasis) bone diseases. Their high affinity for biominerals allows prolonged storage within bone. However information about molecular impact of BP on bone quality are missing. Better understanding of BP properties to optimize their clinical use is needed. The aim of this study was thus to investigate human bone physicochemical changes upon BP uptake.<p class="abs...

ba0005p81 | Bone Marrow | ECTS2016

Increased bone marrow adiposity in energy deficit context: tip of the iceberg?

Ghali Olfa , Leterme Damien , Coutel Xavier , Resonet Anne , Marchandise Pierre , Miellot Flore , Penel Guillaume , Hardouin Pierre , Chauveau Christophe

Context: An increase in bone marrow adiposity (BMA) is usually described in anorexia nervosa (AN) patients and in calorie restriction models. This induced BMA could be involved in the development of the osteoporosis often described in AN. However, BMA increase is not always observed and could be depending on the severity of the deficit.We previously developed the separation-based anorexia mouse model (SBA)1 (Ethical approval CEEA #022012). SBA...