ba0005p158 | Cell biology: osteoblasts and bone formation | ECTS2016
, Drabek Ksenija
, Eijken Marco
, Peppel Jeroen van de
, van Leeuwen Johannes
Activins belong to the transforming growth factor-β superfamily, and they regulate bone formation by controlling both osteoclast and osteoblast behaviour. We have previously shown that activin-A strongly inhibited matrix mineralization in osteoblast cultures, and that activin A-signalling was most effective before the onset of mineralization.The aim of this study was therefore to investigate how an early activin-A pulse affected osteoblast mineraliz...