Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp257 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures

Foger-Samwald Ursula , Afarin Alaghebandan , Patsch Janina , Schamall Doris , Salem Sylvia , Mousavi Mehdi , Pietschmann Peter

Fractures of the hip are serious complications associated with osteoporosis. In previous work we found evidence of osteoblast dysfunction in middle aged men with idiopathic osteoporosis. The aim of this study was to investigate gene expression and bone microarchitecture in bone samples derived from elderly men with osteoporotic hip fractures. Femoral heads and adjacent bone tissue from 12 men with low-trauma hip fractures (mean age 82±7 years) and consecutive surgical hip...

ba0005p261 | Muscle, physical activity and bone | ECTS2016

Bone and muscle metabolism in lung transplant recipients

Foger-Samwald Ursula , Petrikic Aleksandra , Gruther Wolfgang , Ebenbichler Gerold , Kudlacek Stefan , Pietschmann Peter

Although it is well established, that quality of life improves in patients after lung transplantation (LTx), severe musculoskeletal complications may develop. The aim of this study was to evaluate differences in the muscle markers Myostatin and Follistatin and the bone markers Dickkopf-1 (DKK1), Sclerostin (SOST) and Periostin between LuTx recipients and healthy controls. From 38 LTx patients blood samples were taken when discharged from hospital (LTx1) and 6-9 months after di...

ba0007p79 | (1) | ICCBH2019

Novel imaging approaches to the quantification of musculoskeletal alterations in X-linked hypophosphatemic rickets (XLH)

Raimann Adalbert , Mehany Sarah N , Feil Patricia , Weber Michael , Boni-Mikats Andrea , Klepochova Radka , Krssak Martin , Pietschmann Peter , Haeusler Gabriele , Schneider Johannes , Raum Kay , Patsch Janina

Objectives: X-linked hypophosphatemia (XLH) is a rare genetic disorder of phosphate metabolism caused by mutations in the PHEX gene. This pilot study aims to apply novel imaging techniques to asses the musculoskeletal phenotype of XLH patients by bidirectional axial transmission (BDAT) ultrasound, magnetic resonance spectroscopy (MRS) and high resolution peripheral quantitative computed tomography (HR-pQCT).Methods: BDAT bone ultrasound of the radius and...

ba0003pp112 | Cell biology: osteoblasts and bone formation | ECTS2014

Levels of circulating vesicular microRNA-31 increase with age as well as in the case of osteoporosis and inhibit osteogenic differentiation capacity of mesenchymal stem cells

Weilner Sylvia , Schraml Elisabeth , Wassermann Klemens , Wieser Matthias , Messner Paul , Schneider Karl , Micutkova Lucia , Fortschegger Klaus , Maier Andrea B. , Westendorp Rudi , Resch Heinrich , Wolbank Susanne , Redl Heinz , Jansen-Durr Pidder , Pietschmann Peter , Grillari-Voglauer Regina , Grillari Johannes

Aging is a complex process that results in the decline of physiologic functions due to accumulation of damage in cells and tissues. Mesenchymal stem cells (MSCs) counteract this decline but their regeneration capacity decreases with age. In particular osteogenic differentiation potential of MSCs has been shown to decrease with age thereby contributing to slowed down bone formation and osteoporosis. While much is known about cellular aging of MSCs, little is known about factors...