Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p169 | Cell biology: osteoblasts and bone formation | ECTS2016

Iron deficiency increases osteoblast function via Wnt5a

Baschant Ulrike , Platzbecker Uwe , Rauner Martina , Hofbauer Lorenz

Iron overload due to hemochromatosis or chronic blood transfusions has been implicated in the development of osteoporosis. However, the impact of iron overload or iron deficiency on stromal cell functions and the underlying mechanisms are poorly defined. Since the Wnt signaling pathway is a critical regulator of bone remodelling, we aimed to analyse the effects of iron overload and iron deficiency on osteoblast function and further define the role of Wnt signaling in these pro...