Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p205 | Cell biology: osteoclasts and bone resorption | ECTS2016

Better understanding the potency and cytotoxicity of different bisphosphonates on murine osteoclast formation and activity: implications for its better clinical use in treatment cancers

Razai Mohammad , Orriss Isabel , Arnett Timothy

Bisphosphonates are widely used drugs in the fight against osteoclast-mediated bone loss, including osteoporosis and Paget’s disease of bone. The first generation of these potent drugs such as clodronate, a non nitrogen-containing bisphosphonate, has been shown to inhibit osteoclast formation and osteoclastic bone resorption both in vitro and in vivo as well as inducing apoptotic cell death. Recent interest has centred on the effects of more potent nitro...