Searchable abstracts of presentations at key conferences on calcified tissues

ba0002op9 | (1) | ICCBH2013

Anticalciuric effect of recombinant PTH in patients with activating mutations of the calcium-sensing receptor causing autosomal dominant hypocalcaemia--hypercalciuria

Rothenbuhler Anya , Allgrove Jeremy , Coutant Regis , Kapelari Klaus , Bessenay Lucie , Isnard Myriam , Hogler Wolfgang , Linglart Agnes , ESPE Working Group on Bone and Growth Plate

Background: Most patients with hypoparathyroidism are controlled under conventional treatment with calcium and vitamin D analogues. However, this treatment may be difficult to manage, especially in patients with ADHH who have an increased risk of nephrocalcinosis and chronic renal insufficiency. ADHH is caused by activating mutations in the calcium-sensing receptor (CaSR) resulting in suppressed PTH secretion and decreased calcium reabsorption within the thick ascending limb o...