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ba0003pp294 | Osteoporosis: treatment | ECTS2014

Targeting the sealing zone, a novel strategy to prevent bone degradation while maintaining bone formation: in vivo proof of concept in three models of pathological bone loss

Vives Virginie , Cress Gaelle , Richard Chrtistian , Blangy Anne

Molecules secreted by the osteoclast or ‘clastokynes’ are essential to stimulate bone formation by osteoblasts. Treatments with bisphosphates and Denosumab target osteoclast survival and differentiation. This suppresses bone turnover and is suspected to increase the risk of atypical fractures in the long term. A solution to overcome this is to develop strategies that target selectively the activity of osteoclasts without affecting their survival or differentiation. S...

Bone Abstracts

Targeting the sealing zone, a novel strategy to prevent bone degradation while maintaining bone formation: in vivo proof of concept in three models of pathological bone loss

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