Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp198 | Cell biology: osteoblasts and bone formation | ECTS2013

Estrogen effect on the sclerostin induction by BMP-2 in human mesenchymal stromal cells

Kim In Sook , Yang Hoon Joo , Song Yun Mi , Ryu Soo Jin , Kim Ri Youn , Hwang Soon Jung

Introduction: Estrogen therapy decreases circulating levels of sclerostin, a protein product of SOST which increase in postmenopausal women. However, the mechanisms of estrogen on the expression of SOST remain unclear. This study was hypothesized that estrogen modulates SOST expression by interfering bone morphogenic protein (BMP) signaling on the basis that BMP is an inducer of SOST in osteoblasts.Description of methods: We investigated the expression o...