Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp149 | Cell biology: osteoblasts and bone formation | ECTS2014

Telomerase promotes osteoblast differentiation by modulating IGF-signaling pathway

Saeed Hamid , Qiu Weimin , Li Chen , Flyvbjerg Allan , Abdallah Basem , Kassem Moustapha

The molecular mechanisms underlying telomere shortening and telomerase deficiency contributing to defective age-related bone formation are poorly studied. We have previously demonstrated the role of telomerase re-activation in enhancing osteoblast differentiation of BMSCs in vitro and in vivo. Here, we investigated further the signaling pathways underlying the regulatory function of telomerase in osteogenesis. Comparative microarray analysis of telomerase-ove...