Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp130 | Cell biology: osteoblasts and bone formation | ECTS2014

Decrease of mineralization by FGF1 is linked to up-regulation of ANKH and OP in osteogenic differentiation and conversion

Simann Meike , LeBlanc Solange , Jakob Franz , Schutze Norbert , Schilling Tatjana

Osteoporosis is generally accompanied by the fatty degeneration of the bone marrow. The enhanced deposition of adipocytes may result from adipogenic differentiation of bone-marrow mesenchymal stem cells (MSC) and from the adipogenic conversion of osteoblastic cells respectively. Thus, whether this clinical observation is a cause of the disease or rather a reaction of the afflicted bone marrow remains to be elucidated.Previous microarray and bioinformatic...