Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p33 | Bone biomechanics and quality | ECTS2016

Assessment of changes in collagen associated with advanced glycation end-products in human bone using vibrational spectroscopy

Schmidt Felix Nikolai , Zimmermann Elizabeth Ann , Puschel Klaus , Amling Michael , Vashishth Deepka , Tang Simon , Busse Bjorn

Introduction: Aging, diabetes and other disease conditions are associated with the accumulation of non-enzymatic collagen cross-links (NE-XL) in human tissues. Non-enzymatic cross-links (i.e. advanced glycation end products (AGEs)), occur at the bone collagen level, where they are associated with individuals increased fracture risk caused by bone’s reduced plasticity.Methods: Here, non-destructive Fourier-transform infrared (FTIR) spectroscopy was u...