Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp107 | Cell biology: osteoblasts and bone formation | ECTS2014

Osteoblast-specific overexpression of amphiregulin leads to transient increase in cancellous bone mass in mice

Vaidya Mithila , Lehner Diana , Handschuh Stephan , Jay Freya , Schneider Marlon R , Erben Reinhold G

It is well known that the epidermal growth factor receptor (EGFR), its ligands, and the structurally related receptor ERBB2/neu are expressed in skeletal cells. However, the functions of EGFR ligands in bone cells remain poorly defined. In this study, we employed a transgenic mouse line overexpressing the EGFR ligand amphiregulin (AREG) specifically in osteoblasts under the α1(I)-collagen promoter. AREG-tg mice did not show changes in body weight or gross phenotype. Compa...