Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp165 | Cell biology: osteoclasts and bone resorption | ECTS2014

Foreign body giant cells do not have the capacity to resorb bone

ten Harkel Bas , Schoenmaker Ton , de Vries Teun J. , Everts Vincent

Background: Osteoclasts are unique multinucleated cells that originate from the fusion of monocytes. They are the only cells known to be capable of bone resorption. Interestingly, the foreign body multinucleated giant cell (FBGC) arises from the same lineage as the osteoclast, and they share numerous similar characteristics, among which the expression of tartrate resistant acid phosphatase (TRAcP). Yet, it is not known whether the FBGC has the capacity to resorb bone.<p cl...

ba0005p184 | Cell biology: osteoclasts and bone resorption | ECTS2016

Involvement of integrin beta 2/CD18 in attachment of monocytes to bone

Sprangers Sara , Schoenmaker Ton , Cao Yixuan , Everts Vincent , de Vries Teun J.

Background: Osteoclasts (OCs) are bone-degrading cells that differentiate from the monocyte/macrophage lineage. In human, three monocyte subsets have been identified: classical, intermediate and non-classical monocytes. We have previously demonstrated that comparable numbers of OCs can be generated from these subsets on plastic, but that the number of OCs significantly differs when the monocytes are cultured on bone. It is plausible that the observed differences are associated...

ba0005p197 | Cell biology: osteoclasts and bone resorption | ECTS2016

Effects of TGF-β inhibition on osteogenesis and osteoclastogenesis by periodontal ligament fibroblasts from patients with fibrodysplasia ossificans progressiva

de Vries Teun J. , Schoenmaker Ton , Micha Dimitra , Netelenbos Coen , Pals Gerard , Eekhoff Marelise W. , Bravenboer Nathalie

Background: Fibrodysplasia Ossificans Progressiva (FOP) is a progressive disease characterized by periods of heterotopic ossification, often in ligaments. The underlying mechanism is far from clear, partially due to limited access to patient-derived cell models. Periodontal ligament fibroblasts (PLF) from extracted teeth can potentially be used to study deviant bone remodelling processes in vitro since these cells are derived from actual ligaments. They further provid...