Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p153 | Cell biology: osteoblasts and bone formation | ECTS2016

RhoA and ROCK regulate spreading of osteoblasts

Yang Seungwon , Kim Hyun-Man

When cells detach from or re-attach to the substrates, there is a drastic change in shape. Molecular mechanism by which controls shape upon cell attachment to the substrates was studied in osteoblastic MC3T3-E1 cells in vitro. Most striking feature found in the ovoid cells detached from the substrates was densely packed cortical actin bundles (CAB) encircling cells. Cells lost the CAB upon attachment and spreading on to the substrates. CABs were under control of small...