Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p353 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Dietary potassium intake is beneficial to bone health in Korean adults with low dietary calcium intake: the Korean National Health and Nutrition Examination Survey (KNHANES) (2008–2011)

Kim Jung Hee , Kong Sung Hye , Hong A Ram , Lee Ji Hyun , Kim Sang Wan , Shin Chan Soo

Nutrition is a major modifiable factor that affects bone health. Dietary potassium may act as an alkaline source by neutralizing the acid load and reducing calcium loss from bone.We aimed to evaluate the association between dietary potassium intake and bone mineral density (BMD) in the Korean population. We analyzed data from the Korean National Health and Nutrition Examination Survey (KNHANES) A total of 3135 men aged >50 years and 4052 postmenopaus...

ba0005p368 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Gender-different relationship between body composition and incident fracture risk in Koreans: a community-dwelling prospective cohort study

Kim Jung Hee , Hong A Ram , Choi Hyung Jin , Ku Eu Jeong , Cho Nam H , Shin Chan Soo

Low body mass index (BMI) or body weight is a well-known risk factor for osteoporosis and fragility fractures. However, the relative contribution of lean mass and fat mass on bone health, i.e. fragility fractures is inconclusive.We elucidated the relative contribution of lean and fat mass on fracture risk by group analysis in Korean men and women. This was an ongoing prospective community-dwelling cohort study at Ansung in Korea, begun in 2001. We includ...

ba0001pp512 | Steroid hormones and receptors | ECTS2013

Positive regulation of osteogenesis by bile acid through FXR

Shin Chan Soo , Cho Sun Wook , Park Hyojung , Yang Jae-Yeon , Kim Sang Wan , Park Young Joo , Yim Mijung , Kim Jung Eun , Kim Seong Yeon , An Jee Hyun

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, which functions as bile acid sensor controlling the bile acid homeostasis. We have investigated the role of FXR in regulating bone metabolism in vivo. We have identified expression of FXR in calvaria and bone marrow cells, which was gradually increased during osteoblastic differentiation in vitro. Deletion of FXR in vivo has resulted in significant reduction in bone mineral density by...

ba0005p104 | Cancer and bone: basic, translational and clinical | ECTS2016

Long-term effect of aromatase inhibitor on bone mineral density, trabecular bone score, and hip geometry in postmenopausal women with primary breast cancer

Hong A Ram , Kim Jung Hee , Lee Kyung-Hun , Kim Tae Yong , Im Seock-Ah , Kim Tae-You , Moon Hyung-Gon , Han Wonshik , Noh Dong-Young , Kim Sang Wan , Shin Chan Soo

Background: Aromatase inhibitors (AIs) increase the risk of fracture in patients with breast cancer. Therefore, we aimed to evaluate the long-term effects of AIs on bone health in postmenopausal women with primary breast cancer.Patients and methods: We performed a retrospective longitudinal observational study in patients with breast cancer who were treated by AIs for ≧3 years (baseline T-score >–2.5). Patients with previous anti-osteoporosis...