Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp175 | Cell biology: osteoblasts and bone formation | ECTS2013

Identification of a small molecule kinase inhibitor that enhances osteoblast differentiation of human skeletal (mesenchymal) stem cells through regulation of TGFβ signaling

Siersbaek Majken Storm , Jafari Abbas , Zaher Walid , Chen Li , Kassem Moustapha

Identifying novel molecules that enhance human skeletal (mesenchymal) stem cells (hMSC) differentiation into osteoblastic bone forming cells (OB), may lead to development of new bone anabolic drugs. We have identified Kix, a small molecule kinase inhibitor that enhanced ex vivo OB differentiation and reduced apoptosis of hMSC. We found that Kix targeted undifferentiated hMSC populations and not their differentiated progeny. In addition, Kix increased in vivo ...