Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p452 | Other diseases of bone and mineral metabolism | ECTS2016

Micro-RNA expression profiling in Paget’s disease of bone

Bianciardi Simone , Merlotti Daniela , Sebastiani Guido , Valentini Marco , Gonnelli Stefano , Caffarelli Carla , Evangelista Isabella Anna , Cenci Simone , Nuti Ranuccio , Dotta Francesco , Gennari Luigi

Since their initial discovery, microRNAs (miRNAs) have emerged as critical post-transcriptional regulators of gene expression that are able to modulate bone remodeling. Nonetheless, despite the peculiar and aggressive phenotype of pagetic osteoclasts and the associated increase in osteoblast activity, whether deregulation of miRNAs is involved in Paget’s disease of bone (PDB) remains unknown. Here, we performed a serum miRNA expression profile (Taqman Human MicroRNA Array...

ba0005p108 | Cancer and bone: basic, translational and clinical | ECTS2016

Clinical and experimental evidence suggest a protective effect of Paget’s disease of bone against skeletal metastasization from solid tumors

Merlotti Daniela , Rucci Nadia , Rendina Domenico , Bianciardi Simone , Evangelista Isabella Anna , Ucci Argia , Rotatori Stefano , Sebastiani Guido , Dotta Francesco , Cenci Simone , Strazzullo Pasquale , Nuti Ranuccio , Teti Anna , Gennari Luigi

Paget’s disease of bone (PDB) is a common disorder of bone metabolism characterized by focal areas of excessive and rapid bone resorption and formation, leading to bone pain, deformity and fractures. Despite the well documented increase in the risk of primary bone tumors due to neoplastic degeneration of pagetic tissue, a large retrospective analysis suggested that patients with prostate cancer and PDB have delayed time to bone metastases and improved overall survival tha...

ba0005p367 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

FGF23 and SCL are expressed in carotid plaques and the association between their circulating fractions and fractures differs in relation to comorbidity in elderly individuals

Rotatori Stefano , Corallo Claudio , Merlotti Daniela , Rendina Domenico , Bianciardi Simone , Patti Aurora , Gonnelli Stefano , Evangelista Isabella Anna , Lucani Barbara , Franci Maria Beatrice , Setacci Carlo , Strazzullo Pasquale , Nuti Ranuccio , Dotta Francesco , Gennari Luigi

Sclerostin (SCL) and FGF23 are osteocyte-secreted factors with a major role in bone homeostasis. Despite their skeletal effects and their association with fracture risk in some studies, variations in circulating levels were also described in patients with diabetes (DM), chronic renal failure (CRF) and/or cardiovascular disease (CVD). In order to provide further insight on the relationship between these osteocyte-derived factors, osteoporosis and cardio-metabolic disorders we a...