Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp152 | Cell biology: osteoclasts and bone resorption | ECTS2014

Involvement of LIGHT in multiple myeloma bone disease

Oranger Angela , Brunetti Giacomina , Mori Giorgio , Carbone Claudia , Gigante Isabella , Mongelli Teresa , Taurino Grazia , Rizzi Rita , Mestice Anna , Zallone Alberta , Specchia Giorgina , Colucci Silvia , Grano Maria

Multiple myeloma (MM)-bone disease occurs in 70 to 80% of patients at MM diagnosis, and up to 90% at relapse; skeletal related events cause high morbidity and mortality. MM-bone disease consists of lytic lesions arising as a consequence of an unbalanced bone remodelling due to osteoclast (OC) activation, and osteoblast inactivation. Osteoclastogenesis may be under immune cell regulation through the production of numerous cytokines, such as LIGHT/TNFSF14, a newly identified mem...