Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp189 | Genetics | ECTS2014

A polymorphism in the TGF-β1 gene affects TGF-β1 secretion

Husted Lise , Sorensen Lotte , Stenkjaer Liselotte , Langdahl Bente

Transforming growth factor (TGF)-β1 is the most abundant growth factor in human bone. Several polymorphisms have been described in the TGF-β1 gene (TGFB1). We have previously shown that individuals with the CC genotype of the T29C polymorphism have higher bone mass at the femoral neck. The T29C polymorphism causes a change from leucine to proline at codon 10, which is located in the hydrophobic α-helical part of the signal peptide....