Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp164 | Cell biology: osteoclasts and bone resorption | ECTS2014

Novel highly sensitive ELISA to measure free, bioactive, human soluble RANKL

Suciu Andreea , Breitwieser Andreas

RANKL, the receptor activator of nuclear factor kappa B ligand, is an essential factor for the formation of mature osteoclasts. Together with its receptor RANK and its antagonist Osteoprotegerin (OPG) RANKL is a key regulator in bone metabolism1. RANKL is a membrane-bound protein that can be segregated to a soluble form (sRANKL), whereas only the latter has been reported to be bioactive2. Due to its low circulating levels and the nature of the analyte bin...