Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p349 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Relationships between the trabecular bone score (TBS) and glucose metabolism indices in healthy postmenopausal women

Nawata Kiyoko , Yamauchi Mika , Yamamoto Masahiro , Sugimoto Toshitsugu

Purposes: The trabecular bone score (TBS) is an indicator of cancellous bone microstructure obtained from image analysis with lumbar spine dual-energy X-ray absorptiometry (DXA) scans. A decrease in TBS is considered to be a risk factor for vertebral fracture that is independent of BMD. At the same time, it has been reported that, BMD was higher and TBS was lower in women with type 2 diabetes mellitus (DM), and a decreasing TBS is risk factor for fracture. However, the relatio...

ba0003pp109 | Cell biology: osteoblasts and bone formation | ECTS2014

Advanced glycation end products inhibit the mineralization of marrow stromal cells by binding the receptor for AGEs and increasing TGF-β expression and secretion

Yamaguchi Toru , Notsu Masakazu , Okazaki Kyoko , Tanaka Ken-ichiro , Ogawa Noriko , Kanazawa Ippei , Sugimoto Toshitsugu

We and others have recently showed that patients with type 2 diabetes mellitus (T2DM) have a higher risk for fracture, although they have normal or slightly higher bone mineral density (BMD). These findings suggest that bone fragility in T2DM, which is not defined by BMD, may contribute to fracture risk. Hyperglycemia accelerates the formation of advanced glycation end products (AGEs) and causes diabetic complications. AGEs including pentosidine are also known to cause bone fr...