Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p190 | Cell biology: osteoclasts and bone resorption | ECTS2016

Identification and characterisation of vesicles in resorbing osteoclasts using electron tomography

McDermott Emma , Sunderhauf David , Mackenzie Kevin , Wilkinson Debbie , Helfrich Miep

Osteoclasts are the only cell type capable of resorption of mineralised matrix such as bone or dentine. Resorbing osteoclasts form distinct membrane domains: the functional secretory, the basolateral and the ruffled border (RB) domains. The RB allows acidification of the resorption lacuna, exocytosis of osteolytic enzymes and uptake of degraded bone material, processes that require directed vesicular transport. Few studies have tried to classify the vesicles near the RB into s...