Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp211 | Muscle, physical activity and bone | ECTS2014

The peroxisome proliferator-activated receptor α agonist fenofibrate improves the effect of high-impact exercise on bone and muscle mass in ovariectomized rats

Mosti Mats Peder , Ericsson Madelene , Syversen Unni , Stunes Astrid Kamilla

Estrogen deficiency promotes bone loss and skeletal muscle dysfunction. Peroxisome proliferator-activated receptor (PPAR) agonists and high-impact exercise both affect musculoskeletal properties. Whereas PPARδ agonists ameliorate training response in muscle, PPARα agonists exert beneficial effects in bone and muscle. In the present study we investigated the effects of the PPARα agonist fenofibrate and high-impact jumping exercise alone and combined in ovariectom...

ba0003pp63 | Bone development/growth and fracture repair | ECTS2014

Adiponectin induce elasticity of bones

Haugen Sigrid , Sundaresan Alamelu , Tiainen Hanna , Stunes Kamilla , Syversen Unni , Gordeladze Jan O , Reseland Janne

It is known that body weight is positively correlated with increased bone mineral density and decreased fracture risk. Adiponectin is expressed in bone forming cells, and administration of adiponectin has been demonstrated to stimulated osteoblast proliferation. The overall role of adiponectin in bone metabolism remains unrevealed as both stimulated and inhibiting effects on osteoclastogenesis have been reported. We aimed at describing the relationship between adiponectin and ...

ba0005p68 | Bone development/growth and fracture repair | ECTS2016

Adiponectin prevents orthodontic tooth movement in rats

Haugen Sigrid , Matre Aasarod Kristin , Kamilla Stunes Astrid , Peder Mosti Mats , Franzen Tanya , Vandevska-Radunovich Vaska , Syversen Unni , Reseland Janne

Adiponectin may play a role in both bone and periodontal remodeling. In this study, the effect of repetitive local administration of human recombinant adiponectin on experimental tooth movement was examined.The first molar of 24 male Wistar rats was moved mesially by a closed coil spring ligated to the molar and anchored to the incisors in front for 14 days, with adiponectin injections every 3rd day. Amount of tooth movement was examined by feeler gauge ...

ba0003oc3.6 | Osteoclasts, gastric hormones and HIF | ECTS2014

Skeletal effects of the gastrin receptor antagonist netazepide in H+/K+ATPase beta-subunit deficient mice

Aasarod Kristin Matre , Koldeh Masoud Ramezanzadeh , Mosti Mats Peder , Stunes Astrid Kamilla , Viggaklev Bjorn Ivar , Reseland Janne Elin , Beisvag Vidar , Sandvik Arne Kristian , Skallerud Bjorn Helge , Syversen Unni , Fossmark Reidar

Epidemiological studies suggest that patients using proton pump inhibitors (PPIs) have increased fracture risk. We have previously shown that H+/K+ATPase beta-subunit knockout (KO) mice have reduced BMD, BMC and mechanical bone strength compared to WT. Like users of PPIs, these mice have elevated serum gastrin levels due to high gastric pH. We wanted to study whether elevated gastrin influences bone quality in these mice.Female KO and WT mice aged 6 week...