Searchable abstracts of presentations at key conferences on calcified tissues

ba0004oc12 | (1) | ICCBH2015

A zebrafish osteogenesis imperfecta model: a new tool to develop novel pharmacological treatments

Gioia Roberta , Tonelli Francesca , Carra Silvia , Cotelli Franco , Bianchi Laura , Gagliardi Assunta , Bini Luca , Biggiogera Marco , Leikin Sergey , Fisher Shannon , Rossi Antonio , Tenni Ruggero , Forlino Antonella

Objectives: Osteogenesis imperfecta (OI) is a bone disease mainly caused by collagen type I mutations and characterized by bone fragility. No definitive cure is available and the search for novel treatments is necessary. The small teleost D. rerio is particularly appealing for drug screening approaches. A zebrafish OI model (Chihuahua) carrying in heterozygosis the G574D substitution in the α1 chain of collagen type I is available. To use this model for ...