Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp13 | Arthritis and other joint diseases: translational and clinical | ECTS2013

Clinical and histomorphometrical assessment of bone quality in hip osteoarthritis and osteoporosis

Feola Maurizio , Rao Cecilia , Celi Monica , Gasbarra Elena , Tarantino Umberto

Osteoarthritis (OA) and osteoporosis (OP) are two diseases characterized by the alteration of bone quality, that affect mainly elderly people reducing their quality of life. Although an inverse relationship between has been shown by some studies, other reports supported the co-existence of these pathologies. In this study we combined clinical and structural features to clarify the relationship between OA and OP.Among all the patients who underwent a tota...

ba0001pp190 | Cell biology: osteoblasts and bone formation | ECTS2013

Role of vitamin D and K on human osteoblasts in vitro on primary cultures derived from osteoporotic and normal patients

Roscetti Gianna , Marini Mario , Arango Emiliano , Tarantino Umberto

This study is focused on the effects of the synergic use of vitamins D and K on human osteoblasts primary cultures derived from osteoporotic and normal patients. The aim of this work is the evaluation of the different cellular behaviour in response to the lipophilic vitamins stimulation. We included 20 osteoporotic and 20 control patients in age between 35 and 50 and in age between 55 and 85. All patients gave informed consent for using bone samples as a source of bone cells. ...

ba0005p371 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Seasonal and environmental effect on the incidence of hip fractures and non hip fractures in Italy

Tarantino Umberto , Feola Maurizio , Rao Cecilia , Guazzini Andrea , Piscitelli Prisco

Background and objective: Data concerning the incidence of fractures in Italy have been displayed since year 2000 by analysing hospital discharge records (HDRs). However, the influence of seasonal and environmental factors on fracture events in the Italian population has not yet been assessed.Methods: We have analyzed HDRs for primary diagnosis of hip, vertebral, forearm, humeral and knee fractures in Italy from year 2007 to 2009. Inferential statistics ...

ba0001pp188 | Cell biology: osteoblasts and bone formation | ECTS2013

Intracellular calcium fluxes in human bone cells in osteoporotic and osteoarthritic patients

celi Monica , Gasbarra Elena , Frank Claudio , Cutarelli Alessandro , Cinci Giulio Fioravanti , Tarantino Umberto

We studied changes in intracellular Ca2+ concentration in bone cell cultures obtained from human subjects with osteoporosis and osteoarthritis, to evaluate differences between these patients and healthy subjects. We enrolled 36 patients: 12 undergoing primary total hip arthroplasty for osteoporotic femoral fractures (group A, mean age range 57–80), 12 for hip osteoarthritis (group B, mean age range 57–80), and 12 healthy subjects who suffered a high-energy...

ba0005p461 | Other diseases of bone and mineral metabolism | ECTS2016

The role of bone morphogenetic proteins in muscle regeneration of osteoarthritic patients

Iundusi Riccardo , Gasbarra Elena , Scimeca Manuel , Pignatale Ilaria , Bonanno Elena , Tarantino Umberto

Introduction: Age-related bone diseases, such as osteoarthritis (OA) and osteoporosis (OP), are strongly associated with sarcopenia and muscle fiber atrophy. Potential mechanisms involved in the reduction of skeletal muscle mass during sarcopenia converge on the failure of satellite cells in replacing and repairing damaged muscle fibers. Myostatin and bone morphogenetic proteins (BMPs) are molecules able to regulate muscle mass homeostasis by activating satellite stem cells [4...

ba0005p466 | Other diseases of bone and mineral metabolism | ECTS2016

Bone histomorphometric alterations and chronic kidney disease in patients with osteoarthritis and osteoporosis

Feola Maurizio , Rao Cecilia , Scimeca Manuel , Buharaja Rodrigo , Scialdoni Alessandro , Tarantino Umberto

Osteoarthritis and osteoporosis are two elderly conditions characterized by two different pathophysiological mechanisms. In patients with chronic kidney disease (CKD), there is a metabolic impairment of the muscular-skeletal tissue. The aim of our study is to evaluate the biochemical and morphostructural alterations in different states of CKD in patients with osteoarthritis or hip fracture.We evaluated all patients undergoing hip replacement surgery from...

ba0001pp359 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Ten years of increasing hip fractures incidence in Italy but first good news from the Analysis of National Hospitalizations Records 2000–2009

Piscitelli Prisco , Feola Maurizio , Rao Cecilia , Celi Monica , Piccirilli Eleonora , Gasbarra Elena , Parri Simone , Iolascon Giovanni , Maria Luisa Brandi , Tarantino Umberto

Objectives: We aimed to evaluate hospitalization rate of femoral neck fractures in the elderly Italian population over ten years.Methods: We analyzed national hospitalizations records collected at central level by Ministry of Health from 2000 to 2009. Age- and sex-specific rates of fractures occurred at femoral neck in people ≥65 years old. We performed a sub-analysis over a 3-year period (2007–2009), presenting data per five-year age groups, ...