Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p162 | Cell biology: osteoblasts and bone formation | ECTS2016

RCOR2 is a novel regulator of osteoblast differentiation

Tarkkonen Kati , Al Majidi Rana , Valensisi Cristina , Saastamoinen Lauri , Hawkins David , Kiviranta Riku

Epigenetic mechanisms regulating osteoblast differentiation are still inadequately described. In a genome wide transcriptional profiling of MC3T3-E1 osteoblastic cell line, we identified RCOR2 as a significantly upregulated gene during a differentiation time-course from proliferative to mature osteoblasts. Similar expression profile of RCOR2 was found in mouse calvarial osteoblasts. RCOR2 belongs to CoREST/RCOR family of proteins that regulate action of lysine-specific histone...