Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp341 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Vitamin D levels in immobilized Spanish adults: the Camargo Cohort Study

Olmos Jose M , Velasco Pilar Garcia , Hernandez Jose l , Martinez Josefina , Cabrero Veronica , Valero Carmen , Gonzalez-Macias Jesus

Objective: To determine serum 25-lydroxivitamin D (25OHD) and intact parathyroid hormone (PTH) levels in an immobilized population from Northern Spain.Subjects and methods: We studied 125 immobilized people (37 men and 88 women) aged 53–101 years. (85±8 years.). Seventy-five percent of the subjects lived at home, residing in nursing homes the remaining 25%. None of them received antiresorptive therapy, corticosteroids or vitamin D supplements. ...

ba0005p456 | Other diseases of bone and mineral metabolism | ECTS2016

Bone mineral density and TBS in patients with mutations of the alkaline phosphatase gene

Lopez-Delgado Laura , Riancho-Zarrabeitia Leyre , Valero Carmen , Tenorio Jair A , Garcia-Unzueta Mayte , Lapunzina Pablo , Riancho Jose A.

Alkaline phosphatase activity is critical for the mineralization of the bone matrix. Indeed, inactivating mutations of the ALPL gene, encoding the isoenzyme expressed in bone and liver, may result in the severe abnormalities of bone and other connective tissues that characterize hypophosphatasia. Nevertheless, the clinical spectrum of hypophosphatasia is rather broad and variable between a within families. Thus, along severe infantile forms, there are adult forms with mild man...

ba0005p143 | Cell biology: osteoblasts and bone formation | ECTS2016

RUNX2, osterix and the human sclerostin gene: searching molecular and epidemiological interactions

Perez-Campo Flor , Santurtun Ana , Garcia-Ibarbia Carmen , Pascual Maria A , Valero Carmen , Garces Carlos , Sanudo Carolina , Zarrabeitia Maria T , Riancho Jose A

Sclerostin, encoded by the SOST gene, functions as an inhibitor of the Wnt pathway and thus it is an important regulator of bone homeostasis. The fact that osteoblasts, the only cells expressing SOST, lay buried deeply in the bone matrix, poses intrinsic difficulties to the study of the regulation of this gene. Since RUNX2 and SP7/OSX are two known regulators of the differentiation of cells of the osteoblastic lineage, the aim of this study was to determine t...

ba0005p309 | Osteoporosis: evaluation and imaging | ECTS2016

Tbs and calcaneal ultrasonography in people with down syndrome

Garcia Hoyos Marta , de Lamadrid Carmen Valero Diaz , Unzueta Carmen Garcia , L Lamosas Sheila Ruiz , Setien Isabel Sierra , Moral Jose Antonio Riancho

Individuals with Down syndrome (DS) have a number of phenotypic features, including a short stature. It has been reported that people with DS have lower areal BMD than the general population, but this may be a biased result due to the smaller size of the skeleton, and it is unclear if individuals with DS have fragile bones. Thus, the objective of this study was to explore the skeleton of DS using two techniques, TBS and calcaneal ultrasound, which are not influenced by bone si...