Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p76 | (1) | ICCBH2019

Safety profile of asfotase alfa treatment of patients with hypophosphatasia: a pooled analysis

Whyte Michael P , Bishop Nick , Hasan Jawad , Hofmann Christine , Hogler Wolfgang , Rockman-Greenberg Cheryl , Sena Veruska , Zhou Shanggen , Kishnani Priya S

Objectives: Asfotase alfa (AA), an enzyme replacement therapy, is the only approved treatment for pediatric-onset hypophosphatasia (HPP). We evaluated the safety profile of AA from the clinical trial program spanning pediatric and adult patients.Methods: Safety data were pooled from 4 open-label, multicenter studies in children aged ≤3 years (study 002/003 [NCT00744042/NCT01205152]; n=11) and ≤5 years (study 010-10 [NCT01176266]; <em...