Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p252 | Genetics and Epigenetics | ECTS2016

Mitochondrial DNA point mutation is associated with lower bone turnover markers

Langdahl Jakob H. , Hansen Stinus J. , Andersen Per H. , Yderstraede Knud B. , Vissing John , Duno Morten , Frederiksen Anja L. , Frost Nielsen Morten

Introduction: Mitochondrial dysfunction is associated with several clinical outcomes including diabetes and myopathy and is implicated in the human aging process. We previously showed that the mitochondrial DNA point mutation mtDNA3243A>G is associated with lower BMD and altered bone structure. The aim of this study was to assess bone turnover markers in individuals with the mutation and controls.Methods: We recruited 45 patients (29 female, 16 male)...