Searchable abstracts of presentations at key conferences on calcified tissues

ba0005oc2.1 | Bone mass and bone strength Wnt signalling | ECTS2016

Targeted deletion of Wnt1 in mesenchymal cells results in decreased bone mass and spontaneous fractures

Wang Fan , Tarkkonen Kati , Nieminen-Pihala Vappu , Rummukainen Petri , Lehto Jemina , Nagano Kenichi , Baron Roland , Makitie Outi , Kiviranta Riku

Wnt signaling is a major regulator of bone metabolism. We recently reported that mutations in WNT1 gene in humans cause early onset osteoporosis and severe osteogenesis imperfecta. To identify the cellular source and the mechanisms causing these severe phenotypes we generated and analyzed global and conditional Wnt1 knockout mice.Heterozygous Wnt1+/− mice were viable and fertile but Wnt1−/− embryos were lost in ute...