Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp158 | Cancer and bone: basic, translational and clinical | ECTS2013

Role of receptor activity modifying proteins in skeletal regulation

Pacharne Suruchi , Richards Gareth , Wang Ning , Skerry Timothy , Caron Kathleen

Receptor activity modifying proteins (RAMPs 1, 2 and 3) are a class of important accessory proteins that interact and regulate several G-protein coupled receptor (GPCR) activity by finely modulating ligand interaction and in some cases trafficking receptors to cell surface.Predominant roles of RAMPs include ligand selectivity in receptors for Calcitonin (CT) family of peptides that comprise calcitonin, calcitonin gene related peptide, amylin and Adrenome...

ba0005p124 | Cancer and bone: basic, translational and clinical | ECTS2016

Gene expression of P2 receptors in mitotically quiescent, prostate cancer bone metastasis initiating cells

Amin Zarkesh Sayyed , Docherty Freyja , Eaton Colby , Wang Ning

Rationale and hypothesis: In ~70% of advanced prostate cancer (PCa) patients, incurable bone metastases are a significant cause of morbidity and mortality. It has been shown that in models of PCa, bone metastases are initiated by a minor subset (<1% of total cell population) that are mitotically quiescent and which have undergone epithelial to mesenchymal transition (EMT). Recent studies have shown that various P2 receptors regulate invasiveness/EMT in different types of c...

ba0001pp57 | Bone biomechanics and quality | ECTS2013

Role of receptor activity modifying protein 3 in the response of bone to mechanical loading

Livesey Matthew , Pacharne Suruchi , Wang Ning , Grabowski Peter , Yang Lang , Richards Gareth , Skerry Tim

Adaptive responses of the skeleton to loading changes architecture and physical properties in order to optimise strength for function. However, bone is subjected to many local and circulating osteotropic factors, most acting on G-protein coupled receptors. Receptor activity modifying protein-3 is a single trans-membrane domain receptor accessory protein, which aids in trafficking of calcitonin and calcitonin-like receptors to the cell surface and changes ligand selectivity. As...