Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p6 | Arthritis and other joint diseases: translational and clinical | ECTS2016

Effects of 17β-estradiol and mechanical overloading on osteoarthritis of rat temporomandibular joint

Hwang Soon Jung , Yang Hoon Joo

Objectives: Sex hormones and mechanical overload have been regarded as main causative factors in the pathogenesis of temporomandibular joint (TMJ) osteoarthritis. However, there was no report regarding the relevance of mechanical overload on the mandibular condyle with serum estrogen level. This study aimed to investigate changes of the mandibular condyle of TMJ in ovariectomized rat under increased loading, and to evaluate the inhibitory effect of systemic administration of 1...

ba0005p7 | Arthritis and other joint diseases: translational and clinical | ECTS2016

Effect of estrogen deficiency on loaded and non-loaded area of temporomandibular or knee Joint

Hwang Soon Jung , Yang Hoon Joo , Seong Yeju

Introduction: Low level of estrogen has regarded as a main contributing factor of temporomandibular joint (TMJ) arthritis in young women patients. However, there is lack of evidence about the occurrence of arthritis in knee joint (KJ) related with estrogen deficiency. This study aimed to investigate the effect of estrogen deficiency on the loaded and non-loaded bone area of TMJ or KJ.Method and materials: Total of 28 SD rats were allocated into two group...

ba0001pp47 | Bone biomechanics and quality | ECTS2013

Osseous alterations in condylar head after directional change of functional loading in rabbit mandibular condyle

Hwang Soon Jung , Yang Hoon Joo , Cho Tae Hyung , Oh Ji Hye , Kim In Sook

Purpose: The purpose of this study was to investigate the bony change of mandibular condyle when the originally less-loaded or unloaded surface was subjected to functional loading by the newly designed animal experiment, and to evaluate whether this experiment is adequate for the animal model of condylar resorption due to mechanical loading.Methods: Twelve adult male New Zealand white rabbits were used. Unilateral oblique vertical body osteotomy (UOVBO) ...

ba0001pp198 | Cell biology: osteoblasts and bone formation | ECTS2013

Estrogen effect on the sclerostin induction by BMP-2 in human mesenchymal stromal cells

Kim In Sook , Yang Hoon Joo , Song Yun Mi , Ryu Soo Jin , Kim Ri Youn , Hwang Soon Jung

Introduction: Estrogen therapy decreases circulating levels of sclerostin, a protein product of SOST which increase in postmenopausal women. However, the mechanisms of estrogen on the expression of SOST remain unclear. This study was hypothesized that estrogen modulates SOST expression by interfering bone morphogenic protein (BMP) signaling on the basis that BMP is an inducer of SOST in osteoblasts.Description of methods: We investigated the expression o...

ba0003pp129 | Cell biology: osteoblasts and bone formation | ECTS2014

Modulation of sclerostin expression by estrogen via BMP-2 signaling in human mesenchymal stromal cells and osteoblasts

Kim Ri Youn , Yang Hoon Joo , Song Yun Mi , Cho Tae Hyung , Hwang Soon Jung , Kim In Sook

Little is known about the molecular mechanisms underlying the interaction between Sclerostin (SOST) and estrogen, showing an inverse relation in clinical data. Therefore, we investigated mechanisms by which estrogen modulates Sost expression at human osteoblastic cell level in association with BMP-2 signaling, which is a potential route of SOST induction. BMP-2 significantly induced SOST expression, which is suppressed by 17β-estradiol (E2) in human mesenchymal s...